This is from https://neurosciencenews.com/obesity-astrocytes-neuropharmacology-23852/.
They may have found what controls fat cells.
Abstract
Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA
The lateral hypothalamic area (LHA) regulates food intake and energy balance. Although LHA neurons innervate adipose tissues, the identity of neurons that regulate fat is undefined.
Here we show that GABRA5-positive neurons in LHA (GABRA5LHA) polysynaptically project to brown and white adipose tissues in the periphery. GABRA5LHA are a distinct subpopulation of GABAergic neurons and show decreased pacemaker firing in diet-induced obesity mouse models in males.
Chemogenetic inhibition of GABRA5LHA suppresses fat thermogenesis and increases weight gain, whereas gene silencing of GABRA5 in LHA decreases weight gain. In the diet-induced obesity mouse model, GABRA5LHA are tonically inhibited by nearby reactive astrocytes releasing GABA, which is synthesized by monoamine oxidase B (Maob).
Gene silencing of astrocytic Maob in LHA facilitates fat thermogenesis and reduces weight gain significantly without affecting food intake, which is recapitulated by administration of a Maob inhibitor, KDS2010. We propose that firing of GABRA5LHA suppresses fat accumulation and selective inhibition of astrocytic GABA is a molecular target for treating obesity.
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16 comments:
Well, if we could control my fat cells, I for one would be grateful. *LOL*
Echoing Bohemian - though both brain cells hurt after reading the text.
Dawn - Unfortunately, mouse models take a while to progress to human trails.
Sue - I got a few fat cells to donate to the trial.
Didn't you ladies notice that the article only applies to males?
My fat cells are controlled by sugar and chocolate. Just thinking about those foods makes the fat cells swell with pride and happiness.
I'm quite sure that some scientist somewhere is delighted at this, but I didn't understand a word of it. My fat cells have proven impervious to all attempts to chase them away, although being married to a great cook and having gourmet cooking as a hobby probably don't help.
Ima gonna need a Technical to Plain English translator for this one.
Well you know what I think so I won't lecture you all about the importance of a whole plant food based diet. There is no magic pill except eating better.
thanks for the scientific info about fat and reduction. It won't happen in my lifetime. I battle with fat; sometimes it wins and sometimes I do.
OH, check my site and let me know if the photo came through.
Stu - I don't think they read the article. Did you, girls?
Bill - Eating grommets can be hard on your gut.
Kathy - Fat pills coming soo... eventually. Not that you would need any.
Lady - Calories is the trick. Eat less.
Susan - Definitely not in mine. And I still can't open the picture. I'm sure it's something on my end not being able to open a class="BiCYpc". I tried just opening the picture with the HTML code and it didn't work either.
We can only hope they're right.
Kirk - And start working faster.
I would really enjoy hearing your synopsis of these issues. Obviously you found something interesting that escapes us because we don't have your analytic abilities. Shall we say. Perhaps an abstract like at the beginning of a medical journal article? Anyway, thanks for always being interesting. Mike
huh?
Cloudia - I guess the main point here is "gene silencing of GABRA5-positive neurons in the lateral hypothalamic area (LHA - part of the brain) decreases weight gain. They are working on medicine to control that area.
Peg - There's a test coming up. Study hard!
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